A Pearcedale woman and a Cranbourne man were both injured in a serious collision in Pearcedale on Thursday afternoon, 10 November.
Officers have been told a car was waiting to turn right from North Road into Middle Road about 4.25pm on Thursday afternoon.
A car travelling along North Road ran into the back of the turning car and forced it onto the wrong side of the road where it was hit by oncoming traffic, police say.
The driver of the turning car, a woman in her 40s from Pearcedale, was taken to hospital in a critical condition.
A 18-year-old woman from Mornington is currently assisting police with their enquires.
The driver of the oncoming vehicle, a man in his 30s from Cranbourne, suffered minor injuries.
Detectives from Major Collision Investigation Unit are currently on scene and wish to speak to anyone who witnessed the crash or with dashcam footage.
Anyone with footage or information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at crimestoppersvic.com.au