Collisions between motorcycles and cars continue to plague the South East following a serious incident in Tooradin on Monday 1 August.
Police believe a male and female were riding a motorcycle in Rutters Reserve just after 7pm before making their way to the South Gippsland Highway.
The rider was initially travelling along the shoulder of the highway but then moved into the left lane and was struck by a vehicle, police say.
The 16-year-old male rider was taken to hospital with non-life-threatening injuries, the 18-year-old female passenger was taken to hospital in a critical condition.
Police say the driver of the vehicle was not injured, and she is assisting police with enquiries.
Anyone who has dashcam footage or any other information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at crimestoppersvic.com.au
It comes on the back of a fatal collision between a motorcyclist and a car in Narre Warren South on Friday 22 July, and another in Clyde North on the same night.
The rider in the Clyde North collision was taken to hospital with critical injuries.
